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BIOETHICS FORUM ESSAY

As a public health researcher interested in brain injuries in sports, I was searching for peer-reviewed literature that examined cultural pressures that cause athletes to minimize symptoms of potentially serious injuries when I came across a 1994 article entitled, “A Little Pain Never Hurt Anybody: A Photo-Essay on the Normalization of Sport Injuries.” The identity… Read more

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#MeToo and Health Research Ethics
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“Improving patient experience” has become the mantra of many health care facilities in a highly competitive and regulated environment. But just what is it about the patient experience that needs to be improved? Will better food and gift bags do the trick? Or are more basic changes required? To answer that question, I turned to… Read more

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This year, The Hastings Center will celebrate its 50th anniversary. The Center was first located on the second floor of my house in Hastings-on-Hudson, N.Y., with some overflow paperwork stored at the home of my neighborhood friend and cofounder, Willard Gaylin. Neither of us had ever run an organization or raised money. I am a… Read more

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A preliminary investigation by Guangdong Province in China of He Jiankui, the scientist who created the world’s first gene-edited babies, found that “He had intentionally dodged supervision, raised funds and organized researchers on his own to carry out the human embryo gene-editing intended for reproduction, which is explicitly banned by relevant regulations.” As bioethics scholars… Read more

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Chinese Bioethicists Respond to the Case of He Jiankui
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Despite the appearance of agreement, scientists are not of the same mind about the ethics and governance of human germline editing. A careful review of public comments and published commentaries in top-tier science journals reveals marked differences in perspective. These divergences have significant implications for research practice and policy concerning heritable human genome editing. The… Read more

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Scientists Disagree About the Ethics and Governance of Human Germline Editing
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The introduction of pre-exposure prophylaxis (PrEP) as a means of preventing HIV infections in those at high risk marked a significant step in the fight against the virus. PrEP involves taking the HIV medicine Truvada or a generic version daily. It is now gradually becoming available across the world, particularly for men who have sex… Read more

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Prevention Optimism: Does It Raise Ethical Questions about PrEP for HIV?
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In their single-minded venture of “producing” (shengchan, in their own word) the world’s first gene-edited babies, He Jiankui and his associates have posed numerous and daunting ethical challenges to China and the world. They can be mapped or identified through these four categories: typical problems related to research ethics; broader political, socio-cultural, and transcultural issues;… Read more

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He Jiankui’s Genetic Misadventure, Part 3: What Are the Major Ethical Issues?
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The National Rifle Association recently condemned doctors who are against gun violence, telling us to stay in our lane. Reducing preventable deaths is the main lane for doctors. And despite thinking that doctors would not be targeted because we are here to help, we are not immune. The tragic shooting at Mercy Hospital in Chicago… Read more

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Calling on Doctors to Take the Lead in Fighting for Gun Control
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In the wake of the recent Twitter fight between the National Rifle Association and U.S. physician groups over whether doctors should speak out about firearm policy issues, we argue that professionalism actually requires that doctors take a leadership role in gun policy debates, even if (in fact, especially if) doing so is politically fraught and… Read more

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Staying in Their Lane: Health Professionals Must Address Gun Violence
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When the world’s first research on editing the genes of human embryos by Chinese scientists was published in an international journal in 2015, a report in the New York Times characterised the key issue involved as “a scientific ethical divide between China and West.” Earlier this year, an article in the magazine Foreign Policy by… Read more

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He Jiankui’s Genetic Misadventure, Part 2: How Different Are Chinese and Western Bioethics?
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In response to news of the world’s first babies born in China from gene-edited embryos, Sam Sternberg, a CRISPR/Cas9 researcher at Columbia University, spoke for many when he said “I’ve long suspected that scientists, somewhere, would rush to claim the ‘prize’ of being first to apply CRISPR clinically to edit the DNA of human embryos,… Read more

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The global scientific community has been unanimous in condemning Chinese scientist He Jiankui, who announced last week that he used the gene-editing technology called CRISPR to make permanent, heritable changes to the genes of two baby girls who were born this month in China. Criticism has focused on Dr. He’s violation of worldwide acknowledgement that… Read more

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CRISPR in China: Why Did the Parents Give Consent?
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