IRB Articles

IRB: Ethics & Human Research

Financial Payments for Participating in Research While Incarcerated: Attitudes of Prisoners

Abstract: The practice of paying prisoners to for their participation in research has long been debated, and the controversy is reflected in the differing policies in the U.S. prison systems. Empirical...
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IRB: Ethics & Human Research

Broad Consent for Future Research: International Perspectives

Abstract: In the United States, final amendments to the Federal Policy for the Protection of Human Subjects (“the Common Rule”) were published on January 19, 2017, and they will take effect...
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IRB: Ethics & Human Research

The Ethics of Net-Risk Pediatric Research: Implications of Valueless and Harmful Studies

Abstract: Net-risk pediatric research encompasses interventions and studies that pose risks and do not offer a compensating potential for clinical benefit. These interventions and studies are central to efforts to improve...
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IRB: Ethics & Human Research

Promoting Research with Organ Transplant Patients

Abstract: Given the numerous questions related to patient selection, surgical technique, and posttransplant care requiring evidence-based answers, transplantation programs should be conducting research with patients waiting to receive an organ...
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IRB: Ethics & Human Research

Advance Directives for Research: How Do They Compare with Surrogates’ Predictions of Older Adults’ Preferences?

Abstract: Surrogates’ decisions and advance directives currently offer the best opportunities for people to participate in research at times of decisional incapacity. We investigated which of these options better reflects an...
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IRB: Ethics & Human Research

Potential Benefits to Families, Children, and Adolescents Enrolled in Longitudinal Qualitative Research

Abstract: Previous research has focused on the risks of research participation but has rarely considered possible benefits. For a study of family decision-making during pediatric bone marrow transplant, we conducted qualitative...
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IRB: Ethics & Human Research

The Need to Track Payment Incentives to Participate in HIV Research

Abstract: Providing incentives is an accepted and common practice in human subjects research, including clinical HIV research. While we know that financial incentives among similar studies can greatly vary, surprisingly...
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IRB: Ethics & Human Research

Therapeutic Misperceptions in Early-Phase Cancer Trials: From Categorical to Continuous

Abstract: Appropriate enrollment in early-phase clinical trials demands that potential research participants understand and appreciate critical study-related information, because discrepancies in understanding or appreciation can potentially invalidate informed consent to participate...
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IRB: Ethics & Human Research

Ethical Issues in the Use of Nudges to Obtain Informed Consent for Biomedical Research

Abstract: While the use of nudges in public health initiatives and in obtaining informed consent to medical treatment recently has received considerable attention and support, there has been little consideration...
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IRB: Ethics & Human Research

A Study of Reliance Agreement Templates Used by U.S. Research Institutions

Abstract: We performed a content analysis of reliance agreement templates from 73 of the top U.S. research institutions ranked by research funding. Of the institutions in our sample, 67.1% used...
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