Because many institutions struggle to determine how best to support their institutional review board programs, we conducted an exploratory study to identify the individual, group, and institutional factors that may influence commitment to the role responsibilities of being on an IRB. We defined this commitment as consisting of time spent preparing for IRB meetings, views of the importance of serving on an IRB, time dedicated to IRB activities relative to other academic committee service, and willingness to attend IRB meetings. Our study suggests that member commitment to IRB role responsibilities may be related to adequate compensation for time spent on IRB activities, serving on an IRB whose chair fosters a supportive group dynamic, IRB size, length of tenure, efficiency of protocol review, receiving training on the ethical and regulatory requirements for research with humans, and attendance of principal investigators at convened meetings.