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Gene Editing

  • Bioethics Forum Essay

    Transcending Borders in the Ethical Oversight of Human Genome Editing

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    Bioethics Forum Essay
    The bioethics and legal communities must come together to find ways to move with the same ease of the scientific research community--to transcend the geopolitical borders and jurisdictional concerns that make international regulation so difficult.
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  • Bioethics Forum Essay

    Chinese Bioethicists: He Jiankui’s Crime is More than Illegal Medical Practice

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    Bioethics Forum Essay
    Professionals and the public in China first learned of the jail sentence of He Jiankui from the report of Xinhua News Agency. No information, including any interpretation, was provided by the Court. But the reported words of the sentence are so ambiguous as to leave room for different interpretations. We believe that the public has the right to know more than Xinhua News Agency reported.
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  • Hastings Center News

    Hastings Center Scholars Respond to Prison Sentence of Researcher Who Created First Gene-Edited Babies

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    Hastings Center News
    The Compassionate Use Advisory Committee, headed by Hastings Center Fellow Arthur Caplan, of NYU Langone, received the Reagan-Udall Foundation for the Food and Drug Administration’s Innovation Award. The committee was recognized for transforming how expanded access requests, also known as compassionate use requests, are granted by drug developers.
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  • Hastings Center News

    Yes, We’re Animals: Why We Should Face Up to This Reality Now

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    Hastings Center News
    In an age of new biotechnologies, from gene editing to neural enhancement, is there a tension in the idea that humans have special value because they’re somehow different or exceptional in nature? Dwelling on the idea that there’s something extraordinary about being human – and ignoring our kinship with life on our planet – is becoming a problem, says Melanie Challenger, an award-winning British writer and a member of the Nuffield Council on Bioethics who has been a visiting scholar at The Hastings Center in November.
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  • Hastings Center News

    Five Things Bioethicists See in Our Future

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    Hastings Center News
    Bioethicists from the U.S., Canada, and other countries gathered two weeks ago in Pittsburgh for the annual meeting of the American Society for Bioethics and Humanities.  Here are five themes that emerged:
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  • Bioethics Forum Essay

    Hannah Arendt in St. Peter’s Square

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    Bioethics Forum Essay
    Neither one of us expected to be talking about Hannah Arendt at the Vatican. We had been invited to give talks at the Pontifical Academy of Sciences on the scientific and ethical challenges posed by personalized medicine. Walking across the cobblestones of St. Peter’s Square we began to discuss how society regulates biomedical research. Are institutional review boards capable of dealing with innovations like personalized medicine? Are they too bound by regulations? Can they ask larger questions of meaning when simply following the rules won't suffice? And most worrisome, has their bureaucratic function caused them to mistake regulatory compliance for ethical reflection?
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  • Bioethics Forum Essay

    When Might Human Germline Editing Be Justified?

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    Bioethics Forum Essay
    Last month, an international commission convened to consider whether and how germline editing – changing the genes passed on to children and future generations -- should proceed. The discussions focused mainly on the safety risks of the technology, which, while important, are not the only issues to consider. Any conversation regarding germline editing must also honestly and thoroughly assess the potential benefits of the technology, which, for several reasons, are more limited than generally acknowledged.
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  • Hastings Center News

    Watch the Livestream Tonight: Ethics of Technology Keynote Lecture by Hastings Center’s Josephine Johnston

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    Hastings Center News
    The Hastings Center’s director of research Josephine Johnston will explore how parental responsibilities are challenged by new genetic technologies in the keynote address of the “Ethics of Technology,” a yearlong lecture series at Washington & Lee University that begins on September 26.
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  • Hastings Center News

    New Book: Human Flourishing in an Age of Gene Editing

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    Hastings Center News
    New book edited by Hastings Center scholars explores fundamental questions about the nature and well-being of human beings at a time when a revolutionary new biotechnology could permanently change the human species.
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  • Hastings Center News

    Hastings Partners on Unprecedented Genetics Resource Hub

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    Hastings Center News
    The Hastings Center is a collaborator on a major new federally funded center – the Center for ELSI Resources and Analysis — that will fill a void in genetics research by collecting and sharing information about its ethical, legal, and social (ELSI) implications. This resource hub, the first ...
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  • Bioethics Forum Essay

    Why Human Germline Editing Might Never Be Legal in the U.S.

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    Bioethics Forum Essay
    What would it take for the first case of gene editing of a human embryo, egg, or sperm to proceed in the U.S.? Many legal and ethical hurdles involving clinical trials, for starters.
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  • Hastings Center News

    Watch the Livestream: Genomics Enters the Clinic

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    Hastings Center News
    What do patients and DTC genetic test consumers need to know about the clinical applications of genetics? That question was the focus of a recent public event at the New York Academy of Sciences, cosponsosred by The Hastings Center. Read a recap of the highlights and watch the livestream.
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  • Bioethics Forum Essay

    Pursue Public Engagement, but Don’t Expect ‘Broad Societal Consensus’

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    Bioethics Forum Essay
    A prominent group of scientists, bioethicists, and other specialists from around the world recently called for a global moratorium on clinical uses of human germline editing—“changing heritable DNA (in sperm, eggs or embryos) to make genetically modified children.” Before a country allows this...
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  • Bioethics Forum Essay

    Why Avoid the “M-Word” in Human Genome Editing?

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    Bioethics Forum Essay
    It is a truism that good ethics begins with good facts. Here are some of the facts about the ethics and politics of heritable human genome editing from 2015 to 2019.
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  • Bioethics Forum Essay

    Moratorium on Human Genome Editing: Time to Get It Right

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    Bioethics Forum Essay
    Last month, the journal Nature published a call for a global moratorium on heritable human genome editing. Despite criticism, notably from CRISPR pioneer Jennifer Doudna, the moratorium is just what's needed now.
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  • Bioethics Forum Essay

    Chinese Bioethicists Respond to the Case of He Jiankui

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    Bioethics Forum Essay
    A preliminary investigation by Guangdong Province in China of He Jiankui, the scientist who created the world’s first gene-edited babies, found that “He had intentionally dodged supervision, raised funds and organized researchers on his own to carry out the human embryo gene-editing intended for ...
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  • Bioethics Forum Essay

    Scientists Disagree About the Ethics and Governance of Human Germline Editing

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    Bioethics Forum Essay
    Despite the appearance of agreement, scientists are not of the same mind about the ethics and governance of human germline editing. A careful review of public comments and published commentaries in top-tier science journals reveals marked differences in perspective. These divergences have significant...
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  • Bioethics Forum Essay

    He Jiankui’s Genetic Misadventure, Part 3: What Are the Major Ethical Issues?

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    Bioethics Forum Essay
    In their single-minded venture of “producing” (shengchan, in their own word) the world’s first gene-edited babies, He Jiankui and his associates have posed numerous and daunting ethical challenges to China and the world. They can be mapped or identified through these four categories:
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  • Bioethics Forum Essay

    He Jiankui’s Genetic Misadventure, Part 2: How Different Are Chinese and Western Bioethics?

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    Bioethics Forum Essay
    When the world’s first research on editing the genes of human embryos by Chinese scientists  was published in an international journal in 2015, a report in the New York Times characterised the key issue involved as “a scientific ethical divide between China and West.” Earlier this year, an art...
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  • Hastings Center News

    The Hastings Center Celebrates Outstanding Journalists

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    Hastings Center News
    Three journalists received The Hastings Center Awards for Excellence in Journalism on Ethics and Reprogenetics. The awards were presented at an event in New York City on December 6 that celebrated the role of journalists in helping the public understand the science of heredity and the power of geneti...
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  • Bioethics Forum Essay

    He Jiankui: A Sorry Tale of High-Stakes Science

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    Bioethics Forum Essay
    In response to news of the world’s first babies born in China from gene-edited embryos, Sam Sternberg, a CRISPR/Cas9 researcher at Columbia University, spoke for many when he said “I’ve long suspected that scientists, somewhere, would rush to claim the ‘prize’ of being first to apply CRISPR...
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  • Bioethics Forum Essay

    CRISPR in China: Why Did the Parents Give Consent?

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    Bioethics Forum Essay
    The global scientific community has been unanimous in condemning Chinese scientist He Jiankui, who announced last week that he used the gene-editing technology called CRISPR to make permanent, heritable changes to the genes of two baby girls who were born this month in China. Criticism has focused on...
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  • Bioethics Forum Essay

    He Jiankui’s Genetic Misadventure: Why Him? Why China?

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    Bioethics Forum Essay
    The birth of gene-edited twin girls was announced by a young Chinese scientist He Jiankui through one of four self-made promotional videos in English on YouTube (a website officially banned in China) on November 25. Three days later, at the Second International Summit on Human Genome Editing held in ...
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  • Bioethics Forum Essay

    Should We Edit the Human Germline? Is Consensus Possible or Even Desirable?

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    Bioethics Forum Essay
    I started writing this on my way back to New York from the Second International Summit on Human Genome Editing, held in Hong Kong November 27 to 29, where the breaking news of the alleged world’s first birth of genetically edited babies loomed large. The surprising news both reinforced and undercut...
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  • Hastings Center News

    Bioethics Workshop for Secondary School Teachers Examines the Ethics of Human Gene Editing

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    Hastings Center News
    Today’s young people will inevitably grapple with decisions about emerging biotechnologies, such as whether new gene editing technologies should be used to choose the traits of their children or enhance their intelligence. The Hastings Center’s inaugural bioethics workshop for high school teacher...
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  • Hastings Center News

    Should Gene-Edited Mice Be Released to Control Lyme Disease?

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    Hastings Center News
    Hastings Center research scholar Carolyn P. Neuhaus participated in a panel discussion on Martha’s Vineyard on July 12 to discuss a proposal to release genetically modified mice to curb the spread of Lyme disease and other tick-borne illnesses. A Netflix film crew recorded the event, which featured...
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  • Bioethics Forum Essay

    The Only PhD Scientist in Congress Speaks About Truth, Politics, and Human Flourishing

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    Bioethics Forum Essay
    At a time when facts are distorted, disregarded, and ignored in policy making and political discourse, the need in Washington for seekers and defenders of truth has perhaps never been greater. I discussed the state of affairs with Representative Bill Foster, a Democrat from Illinois who prides himsel...
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  • Hastings Center News

    World Science Festival Features Hastings Scholars on Gene Editing

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    Hastings Center News
    Where do we draw the line between safe and dangerous applications of CRISPR, the gene editing technology that allows us to make permanent, even heritable, changes to the genetic code? How should scientists approach public engagement before field testing genetically modified crops in and around commun...
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  • Hastings Center News

    Documentary Series Premiere on Genetic Medicine Features Hastings Scholars

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    Hastings Center News
    Hastings Center president Mildred Z. Solomon and director of research Josephine Johnston were featured speakers at the premiere screening of The Code, a series of three documentaries on the origins of genetic medicine and what its successes and failures mean for the future. The series was produced by...
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  • Hastings Center News

    Should We Pursue Genetic Cognitive Enhancement?

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    Hastings Center News
    That was one of the many questions explored at a public event at the New York Academy of Sciences on May 21, cosponsored by The Hastings Center, the Aspen Brain Institute and the New York Academy of Sciences. “The Enhanced Human: Risks and Opportunities” examined existing and emerging enhancemen...
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  • Hastings Center News

    Hastings Scholar on Public Radio’s “Science Friday”: “Frankenstein” at 200

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    Hastings Center News
    Frankenstein, published 200 years ago this month, asked what it means to be human. In the age of CRISPR and artificial intelligence, that question endures. On Public Radio International’s “Science Friday,” Hastings Center director of research Josephine Johnston participated in a dis...
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  • Hastings Center News

    Responsible Science in a Perilous Time: Hastings and Union of Concerned Scientists Join Forces

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    Hastings Center News
    Climate change, nuclear proliferation, and the advancement of gene editing and other transformative biotechnologies pose enormous global challenges. How can we promote responsible science, good governance, and opportunities for public engagement at time when anti-intellectualism on the rise and socie...
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  • Hastings Center News

    The Hastings Center Plans Genetics Workshop for Science Teachers

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    Hastings Center News
    How can secondary school science teachers help their students think critically about the social and ethical implications of recent advances in gene editing?  The Hastings Center is inviting these teachers to apply for a three-day workshop next summer, which will focus on issues raised by CRISPR/cas9...
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  • Hastings Center News

    Hastings Center Genetics Symposium Draws Journalists from Around the World

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    Hastings Center News
    Is there a parental obligation to create “better” babies? Now that scientists can genetically edit plants and animals for agricultural and other purposes, what can we learn from the longstanding international debate over GMOs?
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  • Bioethics Forum Essay

    Do We Have a Moral Obligation to Genetically Enhance our Children?

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    Bioethics Forum Essay
    The Oxford philosopher Julian Savulescu, among others, has argued that prospective parents engaging in embryo selection using preimplantation genetic diagnosis not only may seek to have genetically enhanced children but are morally obligated do so. (See, for example, his essay “Procreative Benefice...
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  • Hastings Center News

    Josephine Johnston Tackles Gene Editing in “Prestigious Speaker” Series

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    Hastings Center News
    Using gene editing to modify genes responsible for devastating illnesses such as cystic fibrosis seems overwhelmingly desirable, but could there be unintended consequences? Might the ability to select for certain traits in human embryos increase discrimination or merely reflect it? These were two of ...
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  • Hastings Center News

    Breakthrough Cancer Treatment: Hastings Scholars Discuss Hope and Challenges in Health Affairs

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    Hastings Center News
    The first gene therapy for cancer, approved by the Food Drug Administration in August, will transform the treatment of a particular kind of cancer in children and young adults.  It’s transformative because it uses a patient’s own immune cells to attack the cancer cells. The hope is that this is ...
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  • Bioethics Forum Essay

    Is it Ethical for Scientists to Create Nonhuman Primates with Brain Disorders?

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    Bioethics Forum Essay
    In early 2016, Nature published a letter from a group of Chinese researchers reporting that they had created rhesus macaques with “autism-like” behaviors. The macaque was bred with a mutation in the MeCP2 gene. Overexpression of MeCP2 is found in MeCP2 duplication syndrome, a disorder that shares...
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  • Hastings Center News

    International Conference Co-Organized by Hastings Examines the Ethics of Gene Editing

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    Hastings Center News
    Following recent advances in gene editing technologies, including the first recorded use of CRISPR/Cas9 in human embryos in the United States, The Hastings Center cosponsored an international conference, “Genome Editing: Biomedical and Ethical Perspectives,” which took place in Belgrade, Serbia f...
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  • Hastings Center News

    Natalie Kofler: What Role Should Humans Play in “Editing Nature”?

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    Hastings Center News
    Natalie Kofler, a postdoctoral research scientist at Yale University, visited The Hastings Center earlier this summer to explore the ethical questions surrounding the use of gene editing technologies in the environment. Kofler shared insights from the Editing Nature summit, which brought together a m...
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  • Hastings Center News

    Hastings Center Welcomes Inaugural Rice Family Postdoctoral Fellow in Bioethics and the Humanities

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    Hastings Center News
    Joel Michael Reynolds has joined The Hastings Center as its first Rice Family Postdoctoral Fellow in Bioethics and the Humanities. The fellowship is supported by the National Endowment for the Humanities and private donors.
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  • Hastings Center News

    Is it Ethical to Use Genetic “Evolutionary Rescue” for Conservation?

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    Hastings Center News
    Hastings Center research scholar Gregory Kaebnick participated in a multidisciplinary workshop at the University of Montana in Missoula on May 25 – 26 to examine the potential for using genome editing to conserve plants and animals that are threatened with extinction. The meeting addressed scie...
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  • Hastings Center News

    Hastings President Addresses National Conference on the Wise Use of Emerging Technologies

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    Hastings Center News
    Hastings Center president Mildred Solomon  delivered a keynote address at the Future of Medicine conference, a national health care conference celebrating the convergence of technology, bioethics, population health, and preventive medicine. The event, presented by Centura Health in Denver on May 11 ...
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  • Bioethics Forum Essay

    Gene Editing, “Cultural Harms,” and Oversight Mechanisms

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    Bioethics Forum Essay
    Is it reasonable to hope that concerns about “cultural harms” can be integrated into oversight mechanisms for technologies like gene editing? That question was raised anew for me by the recent National Academy of Sciences report on human genome editing and at a recent conference at Harvard on the...
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  • Hastings Center News

    Hastings Center Organizes Symposium for International Journalism Conference: Ethical Debates on New Genetic Technologies

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    Hastings Center News
    The Hastings Center is working with the World Conference of Science Journalists to organize a pre-conference symposium, “New Genetic Technologies: Ethical Debates and Global Science Policy.” The 10th World Conference of Science Journalists, which will take place in San Francisco on October 26 ...
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  • Hastings Center News

    Association of Health Care Journalists Meeting Features Hastings Center Experts

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    Hastings Center News
    The Hastings Center teamed up with the Association of Health Care Journalists (AHCJ) to create three sessions on gene editing for its annual meeting in Orlando on April 20. In addition, Hastings Center research scholar Nancy Berlinger was a panelist on a session concerning health care for refugees an...
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  • Hastings Center News

    Hastings Center Scholar Participates in Isaac Asimov Memorial Debate on De-Extinction

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    Hastings Center News
    Seated on a stage with a museum model of a dodo and a pair of mammoth tusks, a panel of experts debated what is exciting and what is frightening about scientific efforts to bring back extinct species — particularly those lost because of human activity.
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  • Bioethics Forum Essay

    Engineering Consensus in the Development of Genome Editing Policy

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    Bioethics Forum Essay
    In the past few weeks media outlets have been reporting on the release of Human Genome Editing: Science, Ethics, and Governance from the National Academies of Science, Engineering, and Medicine. The report concluded that following more research, it would be ethical to initiate clinical trials using h...
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  • Hastings Center News

    What Does It Mean to Be Human?

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    Hastings Center News
    World-renowned theologian Harvey G. Cox, Jr. came to The Hastings Center for a wide-ranging conversation about the impact of gene editing on humanity. Joined by Daniel Callahan, cofounder of The Hastings Center, Cox discussed questions of governance, parenthood, and personhood.
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  • Hastings Center News

    Watch The Hastings Center’s Symposium on Gene Editing at AAAS Annual Meeting

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    Hastings Center News
    A symposium organized by The Hastings Center for the AAAS annual meeting took place on February 17. Click here to watch. “The Ethics of Gene Editing: Should Concerns Beyond Safety Matter in Science Policy?” discussed a major report released this week, which opens the door to the genetic modificat...
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  • Bioethics Forum Essay

    Human Gene Editing Report: Moving Forward Incrementally

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    Bioethics Forum Essay
    It’s the conversation that really interests me. The NASEM report is plop in the middle of a national and indeed a global inquiry into how genetic science can let us tweak the world—human beings, human nature more generally, other organisms, ecosystems, the biosphere at large. What are the terms of that inquiry?
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  • Hastings Center News

    Playing God: From Frankenstein to Gene Editing

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    Hastings Center News
    What lessons does Frankenstein hold for us today, when powerful new technologies such as gene editing and artificial intelligence are bringing us closer than ever to playing God? That question was the focus of  “Spawn of Frankenstein,” a public event that featured Josephine Johnston, dir...
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  • Bioethics Forum Essay

    The Nebulous Ethics of Human Germline Gene Editing

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    Bioethics Forum Essay
    Should scientists pursue research that would enable prospective parents to edit the genes of their future children in ways that could be passed onto subsequent generations? Not for now, according to the organizers of a summit held in Washington DC at the end of 2015. The three day International Summi...
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  • Hastings Center News

    Erik Parens Addresses National Academies on Human Genetic Enhancement

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    Hastings Center News
    What if gene editing technologies such as CRISPR could be used to safely and effectively “enhance” future generations – to make them, for example, better able to perform on IQ tests? Hastings Center senior research scholar Erik Parens addressed that question at a public meeting of the National ...
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