Advances in genomics, neuroscience, synthetic biology, and nanoscience are merging with advances in computing and artificial intelligence, giving humans powers we have never had.  In the 20^th century, we had to make decisions about the life of a single person. Today, we can make changes to the human genome that are permanently heritable and will reverberate across generations in perpetuity. The Hastings Center’s work in this focus area is to guide the use of these new, highly transformative powers most responsibly.