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E&HR Supporting Information

Sugarman et al., Supporting Information


Reported Participation Benefits in International HIV Prevention Research with People Who Inject Drugs

Jeremy Sugarman, Ilana Trumble, Erica Hamilton, Riza Sarasvita, Kostyantyn Dumchev, Ha Viet, Irving Hoffman, William Miller, and Brett Hanscom


Table 1.

Baseline Characteristics of Participants


Indexes

N (%)

Partners

N (%)

Enrolled

484


774


Self-identified gender

Female

75

(15.5%)

89

(11.5%)

Male

409

(84.5%)

685

(88.5%)

Age (years)

18-19

1

(0.2%)

5

(0.6%)

20-29

80

(16.5%)

215

(27.8%)

30-39

317

(65.5%)

391

(50.5%)

40+

86

(17.8%)

163

(21.1%)

Education

Did not complete secondary school

182

(37.6%)

247

(31.9%)

Completed secondary school or beyond

302

(62.4%)

527

(68.1%)

Relationship status

Married or living with sexual partner

238

(49.2%)

387

(50.0%)

Other

246

(50.8%)

387

(50.0%)

Unemployed in last three months

Yes

291

(60.1%)

431

(55.7%)

No

193

(39.9%)

343

(44.3%)

Employment status

Employed full or part time

273

(56.4%)

479

(61.9%)

Other

211

(43.6%)

295

(38.1%)

Homeless in last six months

Yes

35

(7.2%)

59

(7.6%)

No

449

(92.8%)

715

(92.4%)


Appendix


Reported Participation Benefits in International HIV Prevention Research with People Who Inject Drugs

Jeremy Sugarman, Ilana Trumble, Erica Hamilton, Riza Sarasvita, Kostyantyn Dumchev, Ha Viet, Irving Hoffman, William Miller, and Brett Hanscom


Tables A1-A6: Estimated Relative Risks and P-Values for Predictors of Benefits from Poisson Regression Models with Robust Error Variances. (The binary outcome of a beneficial impact occurring at any time after baseline was modeled.)


Table A1.

Clinical Benefits—Indexes


Predictor

Relative risk (95% CI)

P-value

Age (10-year increments)

1.03 (0.95, 1.10)

0.505

Arm (intervention vs. standard of care)

1.21 (1.12, 1.29)

< 0.001

Education (completed secondary school or beyond vs.

did not complete secondary school)


0.91 (0.83, 0.99)


0.024

Employment status (employed full or part time vs. other)

1.00 (0.92, 1.09)

0.952

Homelessness (yes vs. no)

1.03 (0.88, 1.21)

0.724

Injection frequency (0-10 vs. 11-21)*

1.00 (0.90, 1.12)

0.972

Injection frequency (0-10 vs. 22 or more)*

1.11 (1.02, 1.22)

0.015

Injection frequency (11-21 vs. 22 or more)*

1.11 (1.01, 1.23)

0.038

Prior incarcerations (yes vs. no)#

1.00 (0.83, 1.22)

0.979

Relationship status (married or living with sexual partner vs. other)

1.00 (0.92, 1.08)

0.942

Site (Indonesia vs. Ukraine)

1.16 (1.02, 1.33)

0.027

Site (Indonesia vs. Vietnam)

0.91 (0.82, 1.01)

0.066

Site (Ukraine vs. Vietnam)

0.78 (0.70, 0.88)

< 0.001


For all tables:

* The number of days individuals injected drugs in the month prior to baseline.

# Incarcerated (in jail or prison for involuntary detoxification or another form of incarceration) for some period during the three months prior to baseline.

E&HR


Table A2.

Clinical Benefits—Partners

Predictor Relative risk (95% CI)

P-value

Age (10-year increments) 1.10 (1.04, 1.17)

< 0.001

Arm (intervention vs. standard of care) 0.97 (0.88, 1.07)

0.558

Education (completed secondary school or beyond vs.


did not complete secondary school) 0.97 (0.88, 1.06)

0.472

Employment status (employed full or part time vs. other) 1.05 (0.95, 1.16)

0.335

Homelessness (yes vs. no) 1.13 (0.94, 1.36)

0.205

Injection frequency (0-10 vs. 11-21)* 1.06 (0.94, 1.19)

0.381

Injection frequency (0-10 vs. 22 or more)* 1.14 (1.03, 1.27)

0.014

Injection frequency (11-21 vs. 22 or more)* 1.08 (0.98, 1.20)

0.105

Prior incarceration (yes vs. no)# 0.98 (0.79, 1.21)

0.817

Relationship status (married or living with sexual partner vs. other) 0.90 (0.82, 0.98)

0.013

Site (Indonesia vs. Ukraine) 1.13 (0.97, 1.32)

0.121

Site (Indonesia vs. Vietnam) 0.70 (0.62, 0.80)

< 0.001

Site (Ukraine vs. Vietnam) 0.62 (0.54, 0.71)

< 0.001


image

Table A3.

Social Benefits—Indexes


Predictor

Relative risk (95% CI)

P-value

Age (10-year increments)

1.05 (0.95, 1.17)

0.304

Arm (intervention vs. standard of care)

1.24 (1.12, 1.38)

< 0.001

Education (completed secondary school or beyond vs.

did not complete secondary school)


1.03 (0.90, 1.19)


0.629

Employment status (employed full or part time vs. other)

1.05 (0.93, 1.19)

0.436

Homelessness (yes vs. no)

0.81 (0.62, 1.07)

0.136

Injection frequency (0-10 vs 11-21)*

0.85 (0.72, 1.02)

0.079

Injection frequency (0-10 vs. 22 or more)*

0.97 (0.83, 1.14)

0.693

Injection frequency (11-21 vs. 22 or more)*

1.13 (1.00, 1.29)

0.058

Prior incarcerations (yes vs. no)#

1.10 (0.89, 1.36)

0.382

Relationship status (married or living with sexual partner vs. other)

0.99 (0.88, 1.11)

0.841

Site (Indonesia vs. Ukraine)

0.91 (0.77, 1.08)

0.291

Site (Indonesia vs. Vietnam)

0.87 (0.74, 1.04)

0.121

Site (Ukraine vs. Vietnam)

0.96 (0.82, 1.12)

0.567


2

Table A4.

Social Benefits—Partners


Predictor

Relative risk (95% CI)

P-value

Age (10-year increments)

1.16 (1.06, 1.27)

< 0.001

Arm (intervention vs. standard of care)

0.83 (0.71, 0.98)

0.024

Education (completed secondary school or beyond vs.

did not complete secondary school)


1.14 (0.97, 1.34)


0.110

Employment status (employed full or part time vs. other)

1.04 (0.91, 1.20)

0.538

Homelessness (yes vs. no)

1.26 (1.03, 1.55)

0.026

Injection frequency (0-10 vs. 11-21)*

1.04 (0.87, 1.25)

0.659

Injection frequency (0-10 vs. 22 or more)*

1.06 (0.89, 1.25)

0.524

Injection frequency (11-21 vs. 22 or more)*

1.01 (0.88, 1.17)

0.860

Prior incarceration (yes vs. no)#

0.92 (0.71, 1.19)

0.536

Relationship status (married or living with sexual partner vs. other)

0.94 (0.83, 1.07)

0.350

Site (Indonesia vs. Ukraine)

0.87 (0.72, 1.05)

0.142

Site (Indonesia vs. Vietnam)

0.80 (0.66, 0.97)

0.021

Site (Ukraine vs. Vietnam)

0.92 (0.77, 1.10)

0.351


Table A5.

General Benefits—Indexes


Predictor

Relative risk (95% CI)

P-value

Age (10-year increments)

1.01 (0.97, 1.06)

0.568

Arm (intervention vs. standard of care)

1.12 (1.07, 1.18)

< 0.001

Education (completed secondary school or beyond vs.

did not complete secondary school)


0.95 (0.91, 0.99)


0.029

Employment status (employed full or part time vs. other)

1.01 (0.95, 1.07)

0.735

Homelessness (yes vs. no)

1.00 (0.88, 1.14)

0.973

Injection frequency (0-10 vs. 11-21)*

0.97 (0.90, 1.03)

0.327

Injection frequency (0-10 vs. 22 or more)*

1.06 (1.00, 1.11)

0.035

Injection frequency (11-21 vs. 22 or more)*

1.09 (1.02, 1.17)

0.015

Prior incarceration (yes vs. no)#

0.96 (0.82, 1.13)

0.637

Relationship status (married or living with sexual partner vs. other)

0.99 (0.94, 1.05)

0.783

Site (Indonesia vs. Ukraine)

1.33 (1.22, 1.45)

< 0.001

Site (Indonesia vs. Vietnam)

1.05 (1.01, 1.09)

0.027

Site (Ukraine vs. Vietnam)

0.79 (0.72, 0.86)

< 0.001


Volume 41, Number 5 • September-October 2019 3

E&HR


Table A6.

General Benefits—Partners

Predictor Relative risk (95% CI)

P-value

Age (10-year increments) 1.07 (1.03, 1.11)

0.001

Arm (intervention vs. standard of care) 0.97 (0.90, 1.04)

0.329

Education (completed secondary school or beyond vs.


did not complete secondary school) 0.99 (0.93, 1.06)

0.792

Employment status (employed full or part time vs. other) 1.00 (0.93, 1.07)

0.984

Homelessness (yes vs. no) 1.05 (0.89, 1.24)

0.545

Injection frequency (0-10 vs. 11-21)* 1.06 (0.98, 1.16)

0.152

Injection frequency (0-10 vs. 22 or more)* 1.07 (1.00, 1.15)

0.049

Injection frequency (11-21 vs. 22 or more)* 1.01 (0.93, 1.09)

0.850

Prior incarceration (yes vs. no)# 1.07 (0.92, 1.24)

0.375

Relationship status (married or living with sexual partner vs. other) 1.02 (0.96, 1.09)

0.518

Site (Indonesia vs. Ukraine) 1.69 (1.53, 1.88)

< 0.001

Site (Indonesia vs. Vietnam) 1.06 (1.01, 1.12)

0.027

Site (Ukraine vs. Vietnam) 0.63 (0.56, 0.70)

< 0.001


image

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