On March 9, President Obama removed restrictions on federal funding of research on embryonic stem cell lines derived by means that destroy human embryos. Although members of the President’s Council on Bioethics have been divided on this question and some of our colleagues disagree with us, we think it may be useful and clarifying to set the president’s action in three ways into the context of work the council has done over the past seven years.
- At the outset of his remarks, the president characterized his action as “lift[ing] the ban on federal funding for promising embryonic stem cell research.” That language does not accurately characterize the federal funding policy that has been in place during the entire tenure of this council. The policy announced by President Bush on August 9, 2001, did not ban federal funding of embryonic stem cell research; rather, for the first time, it provided and endorsed such funding (as long as the stem cell lines had been derived prior to that date).
The aim of this policy was not to shackle scientific research but to find a way to reconcile the need for research with the moral concerns people have. That is precisely how the council formulated the question in Monitoring Stem Cell Research: “How can embryonic stem cell research, conducted in accordance with basic research ethics, be maximally aided within the bounds of the principle that nascent human life should not be destroyed for research?”
Attention to the ethical principles that ought to guide and limit scientific research has been constant since the end of World War II. Different kinds of research have been limited, and sometimes prohibited, not in order to suppress science but in order to free it as a genuinely human and moral activity. Whether one agrees or not with the policy that had been in place for more than seven years, clarity and honesty require that we acknowledge its intent: to seek a way for science to proceed without violating the deep moral convictions of many of our fellow citizens.
- In many respects, that policy of seeking a way forward that would not violate widespread moral convictions had in fact succeeded--or, at least, seemed well on the way to achieving its aim. In 2005 this council published a white paper titled Alternative Sources of Human Pluripotent Stem Cells. At its outset, we stated our commitment to two goals: “advancing biomedical science and upholding ethical norms.” We examined briefly four methods that had been proposed for procuring embryonic-like stem cells without destroying human embryos. We were not at that point in a position to endorse without hesitation any of them, but we concluded that we were “pleased to endorse these proposals as worthy of further public discussion, and . . . pleased to encourage their scientific exploration.”
Since the publication of that white paper, researchers have made progress on all of these methods – most strikingly in reprogramming somatic cells in order to restore them to a pluripotent condition. In the last two years, several different groups of scientists have succeeded in producing what are called induced pluripotent stem cells. Because producing them does not require the destruction of embryos, they do not raise what many regard as a grave moral difficulty. Because producing them does not require human ova, and because they are patient-specific stem cells that are less likely to be rejected by their recipients, they also have distinct scientific advantages. Indeed, on the day following President Obama’s announcement, an analysis in the New York Times noted that the embryonic stem cell research the president had touted “has been somewhat eclipsed by new advances.”
It is also worth noting here the position adopted by our predecessor body, the National Bioethics Advisory Commission, which did important work during the Clinton administration. NBAC approved stem cell research using (and, of course, destroying) embryos remaining after in vitro fertilization treatments. At the same time, however, NBAC stated that such embryo-destructive research is justifiable “only if no less morally problematic alternatives are available for advancing the research.” Such alternatives are now available, and research on them is advancing.
With respect to the progress that had been made in reconciling the needs of research and the moral concerns of many Americans, we can only judge, therefore, that the president’s action has taken a step backward, and we regret that.
- In his remarks on March 9, President Obama promised to “ensure that our government never opens the door to the use of cloning for human reproduction.” While this may seem comforting, it stands in need of clarification.
The president’s announced policy would permit federal funding of research not only on stem cell lines derived from “spare” IVF embryos but also on lines derived from created and/or cloned embryos. In the latter two cases, we would be producing embryos simply in order to use them for our purposes.
What researchers most desire, in fact, are not spare IVF embryos but cloned embryos, produced in order to study disease models. The funding decision announced by the president on March 9 will encourage such cloning. Nor should we be reassured that, at the same time, the president opposed “the use of cloning for human reproduction.” If cloned embryos are produced, they may be implanted and gestated. To prevent that, it will be necessary, as we noted in Human Cloning and Human Dignity, “to prohibit, by law, the implantation of cloned embryos for the purpose of producing children. To do so, however, the government would find itself in the unsavory position of designating a class of embryos that it would be a felony not to destroy.” We cannot believe that this would advance our society’s commitment to equal human dignity.
In fidelity to the work the council has done over the past seven years, therefore, we think it essential to clarify what is at stake in the newly announced policy.
Personal Statement by Edmund D. Pellegrino
As an individual council member, speaking for myself and not the President’s Council on Bioethics, I support the substance of the objections of some council members to recent relaxation of existing policies regarding human embryonic stem cell research. Ethically, I cannot support any policy permitting deliberate production and/or destruction of a human fetus or embryo for any purpose, scientific or therapeutic.
– Edmund D. Pellegrino
Posted by Greg Kaebnick at 03/25/2009 02:34:02 PM | Comments
|Should it not be noted that this commentary comes from hold over members of the Council appointed by George Bush, a Council whose majority views tended to be theologically based, and far removed from mainstream bioethical thinking?|
Posted by: email@example.com ( Email | Visit ) at 3/27/2009 10:24 AM
|These authors maintain that President Obama’s claim to lift federal restrictions on funding of human embryonic stem cell research (hESCR) “does not accurately characterize the federal funding policy that has been in place during the entire tenure of this council” because the intent of the Bush policy was not to restrict federal funding of hESCR, but rather to enable the research to go forward in a morally acceptable way. Even if that was President Bush’s intent – and I am willing to give him the benefit of the doubt – it is mind-boggling to think that research that uses stem cells derived from embryos killed before a particular date (August 9, 2001) is acceptable, but not research that uses embryos killed after that date. How can the date carry such moral weight? If one believes that embryos are people, who must not be killed in research, then what possible significance can the date on which they were killed have? Bush did not offer a moral principle for ethically acceptable research but rather a compromise that did not satisfy either the opponents or proponents of the research.|
As for induced pluripotent cells (iPCs) replacing embryonic stem cells, we still do not know if these cells will work or be safe. From a scientific perspective, research on both hESCs and iPCs should continue until we know the answers to these questions. If it turns out that iPCs are just as effective and safe as hESCs, then certainly to insist on destroying embryos would show insufficient respect for the religious and moral convictions of those who view embryos as having moral standing. However, what is proposed by the former members of the President’s Council is that we ought to stop funding hESCR now, out of respect for the religious and moral convictions of some. I cannot see why this should be so. If hESCR lives up to its therapeutic potential, and iPCs are not an adequate substitute, we may lose the opportunity for therapies and cures that would benefit millions of people. Why should respect for the religious and moral convictions of others trump that?
The council members end by bringing up the bogeyman of reproductive cloning: “If cloned embryos are produced, they may be implanted and gestated.” First, the ability to clone a human embryo does not necessarily mean the ability to create a cloned child. But even if it were possible to implant a cloned human embryo and bring it to birth, it is difficult to imagine a plausible scenario in which this would be done. In the future, it might be possible to create tissue or even organs from stem cells. The point of cloning embryos, as opposed to using embryos created by IVF, is that the embryo could be cloned from a somatic cell of a patient, so that the tissue derived from the stem cells would have the patient’s own DNA, thus theoretically avoiding problems of rejection. The writers worry that an embryo cloned for this purpose could be implanted and gestated. But why would anyone want to do that? If the intention is simply reproduction, IVF embryos are a lot easier to come by. And if the intention is to get an embryo of a particular genome for reproductive purposes, why would an embryo cloned from a sick patient be desirable? Concerns about cloning for reproductive purposes need not preclude cloning for research or eventual therapeutic purposes.
– Bonnie Steinbock, SUNY/Albany
Posted by: gkaebnick ( Email ) at 4/1/2009 8:22 AM
While I grant that it was a Solomon's choice facing then-President Bush in 2001, and that when the embryos were killed cannot easily (if at all) carry the moral weight to justify their use in ESCR, it was a compromise, which denotes some level of give and take, regardless what issue is being discussed. You are absolutely correct; the decision was problematic for all sides of the debate.
But in your characterization, you misstate the reason for objections to ESCR. It is not because destroying embryos would 'show insufficient respect for the religious and moral convictions of those who view embryos as having moral standing.' The objection is that it would show insufficient respect to the embryos, because of their moral standing. By your lights, it is a matter of tolerance and politics; by those opposed to ESCR, it is a matter of ethics and morality.
As for the 'bogeyman of reproductive cloning,' I can think of at least one, maybe more reasons why an embryo cloned from a 'sick' person might be desirable. All it would take is a few sick persons who want to be cloned, and some who are willing to help them do it.
Posted by: firstname.lastname@example.org ( Email ) at 4/1/2009 11:26 PM
|The opposing comments focus attention on religious motives that are not supported by the original letter or Dr. Pellegrino's Statement. |
As to the concerns about implantation of cloned embryos and reproduction by cloning: I remember when we were told that no one would use IVF embryos for anything *other* than babies for parents desperate to hold their own children. That assurance was replaced with, the concepts of “spare embryos that are going to die anyway.” In the meantime, researchers have been intentionally creating "disease-specific" and other human embryos for no other purpose than in order to destroy them for research.
The Council members do not directly address what I consider the most likely unethical result of regenerative medicine and technology. (And, second to misguided attempts to reproduce oneself or a loved one, the most likely reason that "anyone would want to do that.")
How long before we are back where Huxley began his speculation, with future children enhanced or stunted for the purposes of others?
Posted by: email@example.com ( Email ) at 4/4/2009 3:33 AM
|There are certainly a lot of details like that to take into consideration. That is a great point to bring up. I offer the thoughts above as general inspiration but clearly there are questions like the one you bring up where the most important thing will be working in honest good faith. I don?t know if best practices have emerged around things like that, but I am sure that your job is clearly identified as a fair game. Both boys and girls feel the impact of just a moment’s pleasure, for the rest of their lives.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 8/16/2013 2:43 PM
|You are my intake, I possess few blogs and sometimes run out from brand :). "He who controls the past commands the future. He who commands the future conquers the past." by George Orwell.|
Posted by: email@example.com ( Email | Visit ) at 6/3/2014 11:51 AM
|Je me sens vraiment heureux d'avoir vu votre page web et j'ai hâte de fois plus nombreux divertissants lecture ici. Merci encore une fois pour tous les détails,,,|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 10/8/2014 5:02 AM
|Un grand merci pour ce brillant après! De nombreux points ont extrêmement utile. J'espère que vous allez continuer partager vos connaissances autour.|
Posted by: email@example.com ( Email | Visit ) at 10/8/2014 5:05 AM
|By having a healthy way of life you can protect on your own from a variety of health problems. Which include diabetes type 2 symptoms, cardiovascular disease, kidney ailment, getting overweight or obese or anything else. It can also boost your overall quality of life, supplying you with far more vitality to perform everything you really like, much more your confident outlook plus more time for you to spend with your loved ones.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 12/2/2014 4:54 PM
|I offer the thoughts above as general inspiration but clearly there are questions like the one you bring up where the most important thing will be working in honest good faith.|
Posted by: email@example.com ( Email | Visit ) at 12/24/2014 2:59 AM
|Making listings associated with goals and also stuff that must be transformed is a technique that many individuals use. Considering a listing daily will help to maintain your entire goals within viewpoint and enable that you sort out one particular merchandise out there during a period.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 2/3/2015 5:30 PM
|People have different essentials in relation to skin care. Women tend to be certain in relation to beauty, nonetheless, they cannot end up being completely beautiful when they are not in good condition. This is why women are generally studying natural healthy approaches to have them balanced and searching beautiful.|
Posted by: email@example.com ( Email | Visit ) at 3/3/2015 3:06 PM
|These types of medical professionals deal with just the signs not the illness as well as prescribe treatments that might result in the affected individual return over and over, getting them absolutely hooked to the prescription drug sometimes in their life-time. I've hardly ever observed someone treated with the illness completely even with undergoing expensive operations.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 4/18/2015 4:26 PM
|This will likely use a great deal related to the actual bargaining power with the prescription organizations in promoting his or her medications in addition to their links to the doctors as well as the people in politics.|
Posted by: email@example.com ( Email | Visit ) at 4/18/2015 4:26 PM
|It is extremely unusual to discover somebody right here much older than twenty five who isn't in to prescription drug as well as resorts to some kind of pill-popping and other to maintain by themselves healthy.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 4/18/2015 4:27 PM
|Those people who are vegetarians, especially vegans, need to be watchful to not increase an insufficiency in this which may cause depression and also psychological problems. Supplementing of DHA is a vital. Learn to distinguish the difference between quality fatty acids and cheap, horrible trans-fats that define unhealthy foods for any balance diet.|
Posted by: email@example.com ( Email | Visit ) at 4/19/2015 4:25 PM
|I also make a cup of brown rice separately and add that in also.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 4/20/2015 3:38 PM
|Rice is a grain, like corn, very high in fiber and selenium which promotes so many health benefits that another separate article on brown rice especially compared to white rice is well justified.|
Posted by: email@example.com ( Email | Visit ) at 4/20/2015 3:39 PM
|l'affichage des vues sur les sites de laisser la page blog web écrivains savent qu'ils ont participé quelque chose d'utile pour le monde du Web complète.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 4/20/2015 10:52 PM
|It's actually a figure we could play that gives us all agreement to become free, to find each of our childlike spontaneity, creativity and also real joy. This invites us all in order to reconcile towards the fun little one inside.|
Posted by: email@example.com ( Email | Visit ) at 4/23/2015 6:08 PM
|I hаvе beеn іn loоk fоr оf ѕоme information abоut іt аlmoѕt threе time. Yоu served mе а lot іndeed аnd analyzing thіs уour publish I hаve fоund mаnу nеw аnd uѕеful information abоut thiѕ topic. |
targeted email advertising
Posted by: firstname.lastname@example.org ( Email | Visit ) at 5/7/2015 6:59 AM
|You made some decent points there. I looked on the internet for the issue and found most individuals will go along with with your website..|
old school new body recipes
Posted by: email@example.com ( Email | Visit ) at 5/10/2015 7:20 AM
|I hаvе beеn іn loоk fоr оf ѕоme information abоut іt аlmoѕt Three time. Yоu served mе а lot іndeed аnd analyzing Thіs уour publish I hаve fоund mаnу nеw аnd uѕеful information abоut This topic.|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 5/11/2015 6:15 AM
|Scent of varied manufacturers tend to be popular having persons affecting various age ranges. Fashion experienced persons world-wide monitor the modern bunch connected with fragrance start out there. In actuality fragrances perform large location. |
high pr backlinks
Posted by: email@example.com ( Email | Visit ) at 5/12/2015 3:53 AM
|Nice blog right here! Also your website quite a bit up very fast! What web host are you using? Can I am getting your affiliate hyperlink on your host? I want my web site loaded up as quickly as yours..|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 5/12/2015 6:48 AM
|use this very careful))|
Posted by: email@example.com ( Email | Visit ) at 5/12/2015 4:11 PM
|he stem cells would have the patient’s own DNA, thus theoretically avoiding problems of rejection. The writers worry that an embryo cloned for this purpose could be implanted .|
delhi to jaipur cab
Posted by: firstname.lastname@example.org ( Email | Visit ) at 5/13/2015 2:18 AM
|If it became entrenched, such thinking could open the door to other and more insidious forms of genetic reductionism.|
Free Ebook Downloads
Posted by: email@example.com ( Email | Visit ) at 5/14/2015 6:18 AM
|Henry Greely and six other prominent authors published a commentary|
Posted by: firstname.lastname@example.org ( Email | Visit ) at 5/20/2015 6:52 AM